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September 16, 2025

Molecular Noise and Cooperativity Drive Balanced Fate Decisions and Clonal Heterogeneity in Bistable Gene Circuits

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Authors

YKY K Yathu Krishna

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Overview

Analysis reveals how molecular noise influences clonal heterogeneity and gene-regulatory networks in cell fate decisions.

Key Points

  • Molecular noise diversifies cell destinies in populations, balancing A- and B-dominant states.
  • The mean fraction of A-dominant cells stabilizes around 0.5 across replicates, influenced by noise.
  • The study utilized a dry-lab method to model dynamics of genetic toggle switches in clonal populations.
  • Findings highlight the role of molecular noise in promoting phenotypic diversity in genetically identical cells.

Cite This Study

Y K Yathu Krishna (2025) studied this question.

synapsesocial.com/papers/68d4565b31b076d99fa5b130https://doi.org/10.21203/rs.3.rs-7548630/v1
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