A Comparative Clinical Study of Intralesional Platelet-Rich Plasma and Intralesional Corticosteroid in Managing Alopecia Areata : Efficacy and Patient Acceptibility

Background: Alopecia areata (AA) is a common, non-scarring autoimmune disorder characterized by patchy hair loss. Intralesional corticosteroids (ILCs) are the standard treatment, though Platelet-rich Plasma (PRP) has recently gained interest as a regenerative alternative. This study aims to compare the efficacy and patient acceptability of intralesional PRP versus ILCs in the management of AA. A randomized, comparative Methods: clinical study was conducted on 30 patients diagnosed with patchy AA. Participants were divided into two groups: Group A received intralesional PRP injections, and Group B received intralesional triamcinolone acetonide. Both groups underwent treatment at 3-week intervals for a total of 3-4 sessions. Clinical outcomes were assessed using the Severity of Alopecia Tool (SALT) score, photographic evaluation, and patient satisfaction scores (VAS) and MacDonald Hull and Norris Grading System over a 12-week period. Pain during injection and any adverse effects were also recorded to evaluate patient acceptability. Both groups showed significant improv Results: ement in SALT scores (p < 0.05). Group A (PRP) had a slower initial response but comparable regrowth at 12 weeks, with higher patient satisfaction despite injection-site discomfort. Group B (ILC) showed faster regrowth and better MacDonald Hull-Norris grading, but more side effects like skin atrophy and telangiectasia. VAS scores favored Group B (p < 0.05). Adverse effects were minor in both groups, with transient tenderness in PRP and atrophy in ILC. Both intralesional PRP Conclusion: and corticosteroids are effective in treating alopecia areata. While corticosteroids offer a quicker response, PRP provides a favorable safety profile and greater patient satisfaction, making it a promising alternative, especially for long-term management or patients at risk of steroid-related side effects.