Case series reveals unusual lipoma presentations in the head and neck region, suggesting potential diagnostic issues.
Lipomas are slow-growing, benign tumors composed of mature adipocytes and account for 16% to 50% of all benign soft tissue tumors in the human body [1]. They typically present as soft, mobile, painless subcutaneous masses and are most frequently located in the trunk and proximal extremities. Only about 13% of lipomas occur in the head and neck region [2], where they can occasionally present in deeper or functionally critical locations such as the parotid gland, oral cavity, supraclavicular region, parapharyngeal space, and sublingual space. These unusual presentations may mimic other pathologies, including neoplasms or cystic lesions, leading to diagnostic challenges.
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V.V et al. (2025) studied this question.
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