What type of study is this?

This is a Quantitative Study study (also classified as: Cohort Study).

September 16, 2025Frontiers in PhysiologyOpen Access

Integrated bioinformatic analysis reveals the underlying mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation

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Integrated bioinformatic analysis reveals biomarkers related to mitochondria and immune pathways in atrial fibrillation.

Three potential biomarkers were identified for atrial fibrillation, providing insights for diagnosis and treatment.
The expression of biomarkers TP53, HLA-G, and MAPKAPK5 was significantly higher in atrial tissues of AF samples.
Causal effects were assessed using two-sample Mendelian randomization, highlighting MAPKAPK5 as a risk factor for AF.
Functional enrichment analysis indicated associations of biomarkers with immune-related pathways in atrial fibrillation.

Wang et al. (2025) studied this question.

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