This research demonstrates architecturally modified nanopores with tailored ion conduction, suggesting advancements in oligonucleotide sequencing and sensing technologies.
Protein nanopores are essential components of single-molecule oligonucleotide sequencing and sensing devices. Here, we demonstrate that installing additional de novo subunits enables large-scale architectural changes of nanopore complexes. We design de novo proteins that integrate seamlessly with the CsgG pore to form 18-subunit, 315-kilodalton complexes with precisely sculpted pore architectures and tailored ion conduction, opening new possibilities for engineering enhanced nanopores with customized structural and functional properties.
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Schnaider et al. (2025) studied this question.
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