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August 1, 2025Obstetrical & Gynecological Survey

Diagnostic Accuracy of Cell-Free Fetal DNA in Maternal Blood in Detecting Chromosomal Anomalies in Twin Pregnancy: Systematic Review and Meta-analysis

L. Della Valle M. Piergianni Asma Khalil Antonio Novelli Giulio Rizzo Ilenia Mappa Smriti Prasad Barbara Matarrelli Valentina Gatta Liborio Stuppia G. Pagani Maria Elena Flacco F. D’Antonio

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Key Points

Cell-free fetal DNA shows promising accuracy in identifying chromosomal anomalies in twin pregnancies, which can inform management.
The review highlights the previous standard of care for trisomy 21 screening, effective in both singleton and twin pregnancies.
Detection of chromosomal anomalies is particularly crucial due to higher associated risks in twin pregnancies, such as preterm birth.
The findings emphasize the need for advanced screening methods like cell-free fetal DNA for better clinical outcomes in twins.

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Implication

Systematic review reports diagnostic accuracy of cell-free fetal DNA in maternal blood, suggesting effectiveness for twin pregnancy assessment.

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Cite This Study

Valle et al. (2025) studied this question.

synapsesocial.com/papers/68d4566c31b076d99fa5b998 https://doi.org/10.1097/ogx.0000000000001432

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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5Improved diagnostic accuracy by using secondary ultrasound markers in the first‐trimester screening for trisomies 21, 18 and 13 and Turner syndromeRetrospective Study · 2012 · 25 citations

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