What question did this study set out to answer?

To evaluate the efficacy of first-trimester screening strategies combining maternal serum biochemistry and fetal ultrasound for detecting trisomy 21 and other major aneuploidies.

January 1, 2011Prenatal DiagnosisOpen Access

Screening for fetal aneuploidies at 11 to 13 weeks

View Full Paper

Ask AI

Bookmark

To evaluate the efficacy of first-trimester screening strategies combining maternal serum biochemistry and fetal ultrasound for detecting trisomy 21 and other major aneuploidies.
Assessed combined first-trimester screening using fetal nuchal translucency measurement alongside maternal serum free-β-human chorionic gonadotrophin and pregnancy-associated plasma protein-A at 11 to 13 weeks.
Evaluated protocol enhancements involving supplementary ultrasound markers (nasal bone, ductus venosus flow, hepatic artery, and tricuspid valve flow) and split-interval testing (biochemistry at 9–10 weeks and ultrasound at 12 weeks).
Combined measurement of nuchal translucency, free-β-hCG, and PAPP-A detected approximately 90% of fetuses with trisomy 21 and other major aneuploidies at a 5% false-positive rate.
Screening performance improved by incorporating secondary Doppler and anatomical ultrasound markers alongside earlier biochemical sampling at 9 to 10 weeks.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Clinical evaluation demonstrates 90% detection of major fetal aneuploidies in early pregnancy, indicating improved prenatal risk assessment through combined biochemical and ultrasound markers.

Cite This Study

K. H. Nicolaides (2011) studied this question.

synapsesocial.com/papers/69e001c12833447a7e255d9f https://doi.org/10.1002/pd.2637

View Full Paper

Ask AI

Bookmark

Implication

Clinical evaluation demonstrates 90% detection of major fetal aneuploidies in early pregnancy, indicating improved prenatal risk assessment through combined biochemical and ultrasound markers.

Screening for fetal aneuploidies at 11 to 13 weeks

Key Points

Discussion

Implication

Cite This Study

Screening for fetal aneuploidies at 11 to 13 weeks

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider