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September 17, 2025Open Access

Mixed-mobility supported lipid bilayers reveal the modulatory role of immobilized ICAM1 on T cell activation, effector functions and immune synapse organization

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Authors

ALAlexander LeithnerNuffield Orthopaedic CentreAKAudun KvalvaagOslo University HospitalTMTanmay MitraChinese Academy of Medical Sciences & Peking Union Medical College

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Implication

This analysis demonstrates how immobilized ICAM1 affects T cell activation and immune synapse organization.

Key Points

  • Immobilized ICAM1 enhances T cell activation and cytotoxicity while altering immune synapse organization.
  • Selective immobilization of ICAM1 disrupts F-actin flow and shifts TCR signaling to peripheral microclusters.
  • Using mixed-mobility supported lipid bilayers allows researchers to study receptor mechanics in immunity.
  • Full-length ICAM1 promotes stronger effector responses compared to a truncated form lacking cytoskeletal association.

Cite This Study

Leithner et al. (2025) studied this question.

synapsesocial.com/papers/68d4567431b076d99fa5bedfhttps://doi.org/10.1101/2025.09.12.675755
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.1992 · 313 citations
  2. 2Integrin signalling at a glance2008 · 902 citations
  3. 3Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells2019 · 96 citations
  4. 4F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation2012 · 215 citations
  5. 5F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse2015 · 177 citations