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This is a Experimental Study study.

September 17, 2025Journal of NeuroscienceOpen Access

Spatio-temporal dynamics of lateral Na+ diffusion in apical dendrites of mouse CA1 pyramidal neurons

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This study reveals Na+ diffusion dynamics in dendrites, showing rapid signal spread and implications for neuronal function.

Na+ influx leads to rapid lateral diffusion within spiny dendrites, enhancing recovery from local Na+ transients.
Findings indicate that normal diffusion, with a coefficient of 600 µm²/s, is crucial for the clearance of Na+ increases.
Glutamate-evoked Na+ signals spread rapidly, with amplitude decreases and latency increases as distance from stimulation site grows.
Dendritic Na+ diffusion is largely independent of dendrite diameter and spine density, suggesting a uniform spreading behavior.

Nelson et al. (2025) studied this question.

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September 17, 2025Journal of NeuroscienceOpen Access

View Full Paper

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Authors

This study reveals Na+ diffusion dynamics in dendrites, showing rapid signal spread and implications for neuronal function.

Na+ influx leads to rapid lateral diffusion within spiny dendrites, enhancing recovery from local Na+ transients.
Findings indicate that normal diffusion, with a coefficient of 600 µm²/s, is crucial for the clearance of Na+ increases.
Glutamate-evoked Na+ signals spread rapidly, with amplitude decreases and latency increases as distance from stimulation site grows.
Dendritic Na+ diffusion is largely independent of dendrite diameter and spine density, suggesting a uniform spreading behavior.

Nelson et al. (2025) studied this question.

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