Natural Alkaloids From Tabernaemontana corymbosa and Related Network Pharmacology Prediction

The plant Tabernaemontana corymbosa is the famous medicinal plant belonging to the family Apocynaceae, and was well-known for its novel and diverse natural products. Traditionally, the different parts of T. corymbosa were commonly used as folk medicine to treat postpartum recovery, ulcers, fever, and tumors. In the past few decades, the alkaloids from T. corymbosa, including bisindoles, aspidosperma, tacaman, and other types, have been reported to be responsible for its biological activity. As a comprehensive summary of T. corymbosa, a total of 170 alkaloids and more than 100 biological activity items were carefully reviewed and described. Based on the collected information, the potential targets and mechanisms of T. corymbosa alkaloids (TCA) against tumors have also been further predicted using network pharmacology. The results suggested SRC, HSP90AA1, AKT1, EGFR, Bcl2, and PIK3CA may be the key targets for the cytotoxic activity of TCA. Additionally, kyoto encyclopedia of genes and genomes (KEGG) enrichment results suggested the calcium signaling pathway, neuroactive ligand-receptor interaction, MAPK signaling pathway, cAMP signaling pathway, and the pathways in cancer were considered to be its possible pathways of action. This work provides a systematic evaluation of the structural characteristics and biological activities of isolated alkaloids, which may provide a data reference for the future separation, purification, and pharmacological activity findings of T. corymbosa.