Oxygen extraction fraction is differently associated with pathological biomarkers in Alzheimer’s Disease and non-Alzheimer’s dementias

Motivation: Differences in Oxygen extraction fraction (OEF) abnormalities between Alzheimer's disease (AD) and other non-AD dementias are critical for understanding pathophysiological differences and developing tailored treatment strategies, yet they remain uninvestigated. Goal(s): To compare the relationship of OEF with pathological biomarkers−amyloid-beta, amyloid tau index, ptau, age, and Mini-Mental State Examination scores−between AD and non-AD dementia. Approach: We used a novel OEF mapping technique, QQ, to obtain OEF in dementia-related cortical and deep gray matters. Results: In non-AD patients, OEF showed positive associations with amyloid beta, ATI, and MMSE, and a negative association with ptau and age. AD patients did not show these relationships. Impact: This study showed distinct OEF relationships with pathological biomarkers between AD and non-AD dementia, using a new technique, QQ. QQ-based OEF can reveal different roles of oxygen metabolism in various types of dementia, enabling tailored treatment strategies.