Oxygen Extraction Fraction mapping between normal cognition and mild cognitive impairment in an elderly cohort using quantitative BOLD

Oxygen Extraction Fraction (OEF) is a valuable indicator of brain physiology influenced by cognitive impairment and vascular pathology in older adults. Our objective is to explore age-related OEF change for cognitively normal (CN) and Mild-Cognitive-Impairment (MCI) subjects. In this study, 56 elderly participants were recruited. Individuals with MCI resulted in higher OEF compared to CN participants, especially in the occipital lobe (p=0.007). In parietal lobe, we observed an inverse correlation between OEF and age (p=0.026) in CN and positive association between OEF and executive function (p=0.023) in MCI. The results showed an effect of aging and cognitive impairment on OEF