Subclinical dysfunction for overweight people with and without type 2 diabetes using cardiovascular magnetic resonance (CMR) and 4D flow CMR

Motivation: Type 2 diabetes (T2D) is associated with left ventricular (LV) diastolic dysfunction, but the differences in intracardiac function between overweight individuals with and without uncomplicated T2D remain unclear. Goal(s): This study aimed to identify subclinical intracardiac differences using CMR and 4D flow CMR. Approach: CMR was used to measure LV global function, strain, and strain rate, and 4D flow CMR was employed for diastolic biomarker analysis. Classification by stroke volume index (SVi) assessed subclinical dysfunction risk and response to exercise. Results: 4D flow CMR detected diastolic dysfunction in T2D, and improved cardiac function after an exercise intervention in the high SVi group. Impact: This study demonstrates the feasibility of 4D flow CMR to detect early diastolic dysfunction in overweight individuals with and without type 2 diabetes, providing insights for identifying at-risk individuals to improve cardiac outcomes.