Why the study?
Pathological changes in the myocardium may explain the development of two different phenotypes in diabetes mellitus-related cardiomyopathy, but the combined effects of LV geometry, myocardial microcirculation, and tissue characteristics on cardiac deformation remained to be evaluated.
In patients with subclinical T2DM, LV concentric remodeling and myocardial fibrosis correlate with diastolic dysfunction, while perfusion abnormalities and myocardial edema are associated with both systolic and diastolic dysfunction.
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Should not yet change practice in subclinical T2DM; leaves open whether CMR geometry, fibrosis, perfusion and edema define treatable DMCMP phenotypes.
Li et al. (2020) studied this question.
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