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This is a Animal Study study (also classified as: Experimental Study).

September 17, 2025Open Access

Microglial metabolic reprogramming drives cognitive decline in heart failure with preserved ejection fraction

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Research demonstrates that HIF-1 signaling alters microglial function in heart failure, suggesting neuroinflammation drives cognitive decline.

Cognitive decline is linked to microglial metabolic reprogramming in heart failure with preserved ejection fraction, revealing new therapeutic targets.
HIF-1 signaling activation in microglia increases glycolytic metabolism and neuroinflammation, directly affecting cognitive functions.
Using a murine model, conditional deletion of HIF-1 in microglia preserved cognitive performance and white matter integrity in heart failure.
Study identifies Sema4D as a key effector linking metabolic stress in microglia to white matter injury in heart failure.

Patil et al. (2025) studied this question.

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September 17, 2025Open Access

View Full Paper

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Authors

Research demonstrates that HIF-1 signaling alters microglial function in heart failure, suggesting neuroinflammation drives cognitive decline.

Cognitive decline is linked to microglial metabolic reprogramming in heart failure with preserved ejection fraction, revealing new therapeutic targets.
HIF-1 signaling activation in microglia increases glycolytic metabolism and neuroinflammation, directly affecting cognitive functions.
Using a murine model, conditional deletion of HIF-1 in microglia preserved cognitive performance and white matter integrity in heart failure.
Study identifies Sema4D as a key effector linking metabolic stress in microglia to white matter injury in heart failure.

Patil et al. (2025) studied this question.

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