September 13, 2024Nature CommunicationsOpen Access

HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis

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ACAgnieszka CzopikThe University of Texas MD Anderson Cancer Center EMEóin N. McNameeNational University of Ireland, Maynooth VVVictoria VaughnPain and Rehabilitation Medicine

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Experimental study reveals that HIF-2α induces miR-29a to suppress TH1-mediated colitis in mice, indicating a protective metabolic mechanism in intestinal inflammation.

Key Points

HIF-2α-dependent induction of miR-29a restrains TH1 cell activity during intestinal inflammation, attenuating experimental colitis in primary CD4+ T cells.
microRNA screen in primary CD4+ T cells reveals that HIF-2α deletion elevates T-bet levels to worsen colitis, whereas miR-29a mimetics dampen inflammation.
Hypoxia-induced miR-29a signaling highlights a regulatory pathway against gut inflammation, though observations require validation beyond this mouse model.

Cite This Study

Czopik et al. (2024) studied this question.

synapsesocial.com/papers/68e58930b6db6435875253e8 https://doi.org/10.1038/s41467-024-52113-y

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Implication

Experimental study reveals that HIF-2α induces miR-29a to suppress TH1-mediated colitis in mice, indicating a protective metabolic mechanism in intestinal inflammation.

HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis

Discussion

Member takes

Implication

Key Points

Cite This Study

HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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