Optimising Ex-Vivo Hand Imaging at Ultra-High FIeld (7T)

Motivation: Ex-vivo MRI of hand specimens at ultra high field enables unprecedented, non-destructive, high resolution imaging not possible in-vivo. However, it poses a challenge requiring robust methodology and optimisation of vendor sequences that have not previously been reported. Goal(s): Our goal was to determine preparation and acquisition methods for optimised spatial resolution and contrast. Approach: Systematic testing of parameters for PD SPACE was conducted and evaluated with SNR and CNR calculations. Combinations of coils and specimen preparation methods were trialled. Results: We demonstrate optimised methodology and sequence parameter choices enabling high-resolution imaging with superior contrast in ex-vivo hand tissue. Impact: This work provides preparation methods and sequence parameters for imaging of ex-vivo hand specimens at UHF (7T) for high contrast and spatial resolution. This enables improved visualisation of anatomical detail and may be translated to other anatomical regions.