What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Histogram analysis of amide proton transfer imaging for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma

Key Points

APTw histogram analysis may predict response to neoadjuvant chemoradiotherapy in rectal cancer patients, and shows potential for improving treatment planning.
The model comparison indicated that APTw-histogram and combined models performed strongly in predicting complete pathological regression.
Patients were divided into pCR and non-pCR groups based on histological assessment to evaluate the efficacy of imaging methods.
Results support further exploration into APT imaging techniques for informed clinical decision-making in managing locally advanced rectal cancer.

Abstract

Motivation: Predicting response to neoadjuvant chemoradiotherapy (nCRT) is crucial for early stratified management of locally advanced rectal cancer (LARC) patients; however, current radiological studies remain inconclusive. Goal(s): To investigate the potential of histogram analysis applied to pre-treatment amide proton transfer-weighted (APTw) imaging in predicting complete pathological regression (pCR) in patients with LARC undergoing nCRT. Approach: Based on histologic assessment, the patients were divided into a pCR or a non-pCR group. APTw histogram features, apparent diffusion coefficient (ADC), and clinical parameters were analyzed. Results: Histogram analysis of pre-treatment APTw may hold promise as a novel approach for predicting the response of LARC patients to nCRT. Impact: Through the establishment of models and model comparison, the APTw-histogram model and the APTw-clinical combined model demonstrated strong diagnostic efficacy and clinical practicality in predicting LARC patients' responsiveness to nCRT, offering new insights for early clinical decision-making.

Perguntar à IA

Bookmark