Accelerated gradient recalled echo improves subthalamic nucleus delineation in Parkinson's Disease, suggesting better outcomes for deep brain stimulation.
Motivation: To improve outcomes of deep brain stimulation treatment of Parkinson's Disease (PD) by improving visualization of the subthalamic nucleus (STN) in the presence of motion during MRI. Goal(s): To evaluate an accelerated gradient recalled echo (aGRE) at 7T. Approach: In two PD patients, aGRE was compared against conventional GRE and turbo spin echo (TSE) acquisitions. STN delineation was rated by an experienced researcher and a neurosurgeon. Results: In one subject with low motion, GRE and aGRE image quality was better than that of TSE. In the subject with high motion, GRE was unusable but aGRE and TSE were acceptable. Impact: Accelerated GRE at 7T offers improved delineation of the STN despite subject motion during MRI. Motion robustness is crucial, as PD patients are prone to movement, and MRI guides lead placement for effective deep brain stimulation treatment.
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Oh et al. (2025) studied this question.
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