Fluid-suppressed APTw and NOEw MRI as Protein-Related Biomarkers for Differentiating IDH Status in Gliomas

Motivation: Noninvasive identification of IDH status in gliomas is crucial for clinical management but remains challenging. Goal(s): To evaluate APT-weighted and NOE-weighted MRI as biomarkers for distinguishing gliomas with IDH mutations. Approach: Application of APT-weighted and NOE-weighted MRI techniques to analyze in vivo protein-related markers in 34 glioma patients on a 3T MR scanner. Results: Significant differences in fluid-suppressed APT-weighted signals allowed for effective differentiation between gliomas with and without IDH mutations. Impact: The results demonstrated the potential of fluid-suppressed APT-weighted MRI as a noninvasive method to improve diagnostic precision in predicting IDH status and optimize clinical management of gliomas.