Evaluation of glymphatic system activity during sleep-wake states through quantitative CSF measurement using a two-pool water model

Motivation: The glymphatic system is crucial in clearing brain waste, and dysfunction has been linked to neurodegenerative diseases. Understanding this system is essential for advancing our knowledge of brain health. Goal(s): We aim to develop a non-invasive method to assess glymphatic activity in the human brain. Approach: We utilized a quantitative CSF measurement technique with a two-pool model and multi-echo GRASE images. Results: Significant variations in glymphatic activity were observed across different brain regions and were found to be influenced by sleep. Impact: Our method can potentially reveal variations in sleep-influenced glymphatic activity, allowing early diagnosis of Alzheimer's disease.