This study demonstrates manganese-enhanced MRI can identify myocardial viability differences, suggesting its relevance in transplant assessments.
Motivation: Manganese enhanced MRI has shown promise in differentiating viable from non-viable myocardium, yet its potential for assessing the level of myocardial viability is unexplored. Goal(s): To evaluate whether MEMRI can detect viability differences in rat heart transplant models through dynamic imaging of manganese uptake. Approach: Rat hearts were transplanted either immediately or after 18-hour preservation. MEMRI was performed at three phases post-injection to calculate signal intensity ratios (SIR) in myocardial tissue, comparing changes over time between groups. Results: SIR analysis revealed significant viability-dependent enhancement differences, particularly in late-phase imaging, supporting MEMRI's role in early myocardial viability assessment for transplantation. Impact: This study demonstrates that an increase in signal intensity ratio reflects the level of myocardial viability and highlights MEMRI's potential for assessing myocardial viability in transplant models. This semi-quantitative approach could enhance clinical evaluations of myocardial viability.
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Matsuura et al. (2025) studied this question.
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