Metal-Organic Supramolecular Cage based Microenvironment Responsive Nanomedicine for Photodynamic Therapy of Triple-Negative Breast Cancer

Motivation: Due to the high malignancy of triple-negative breast cancer and the lack of effective treatment methods, it is necessary to develop brand-new, safe and efficient treatment approaches. Goal(s): MM nanoparticles could mediate photodynamic therapy, release oxygen and small molecule drugs to enhance the PDT efficacy in situ of the tumor, and could be monitored by MR in real time upon the release of Mn²⁺ from tumor microenvironment-responsive MnO₂ nanoparticles. Approach: Animal model validation and 3.0T MR scan in vivo and in vitro validation Results: In vitro and in vivo studies have shown that MM can mediate PDT and achieve real-time MR monitoring. Impact: Nano carriers (MM) exhibit significant MRI - monitoring ability in vivo during the treatment process, with a longer imaging window and good PDT effects. These MRI - related features show great potential as a therapeutic - diagnostic platform for TNBC treatment using nanomedicine.