Evaluating Magnetization Transfer Ratio and T1 Mapping for Non-Invasive Assessment of Renal Fibrosis in Humans

Motivation: In chronic kidney disease, renal fibrosis is characterized by excessive accumulation of extracellular matrix proteins, leading to a magnetization transfer (MT) effect. Previous animal studies indicated the potential of MT for assessing renal fibrosis. Goal(s): To investigate the clinical significance of MT imaging for assessing renal fibrosis and to compare its efficacy with T1 mapping. Approach: Twenty subjects were recruited, with data collected using two-dimensional breath-hold MTR and T1 mapping techniques. Statistical analysis were conducted with p<0.05. Results: Significant differences in T1 values were found between the control and patient groups; however, no significant differences in MTR were observed between the groups. Impact: This study found no significant difference in MTR between groups with and without renal fibrosis. Future research using quantitative MT imaging techniques on a larger cohort is warranted to understand the clinical utility of MT effect in assessing renal fibrosis.