Experimental results show brain metabolism predicts cold-stress protein increases in hypoxia-ischemia models, suggesting biomarkers for responders to hypothermia.
Motivation: To explore biomarkers for recognizing non-responders to hypothermia Goal(s): To test if the metabolic profile with hyperpolarized 13C MR spectroscopy after hypothermia predicts the upregulation of cold-stress proteins. Approach: Postnatal 10 mouse pups with hypoxia-ischmia (HI) were divided into HI with normothermia, HI with hypothermia and sham groups, and underwent HP-13C MRS scans. Brains were harvested for cold-stress proteins' measurements Results: Anaerobic metabolism was suppressed 4h and 20h after hypothermia and the reduction of Kpl and Lac/Pyr can predict the upregulation of cold stress protein, i.e. CIRP levels. Impact: The cold stress protein, i.e., CIRP levels could be used as one of the hypothermia-regulated targets to promote the TH effect on those who are not responsive to the hypothermia.
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Liu et al. (2025) studied this question.
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