This analysis identifies fatty acid composition biomarkers linked to myocardial perfusion in women with ANOCA, suggesting an impact on cardiac health.
Motivation: Epicardial adipose tissue (EAT) plays a key role in metabolic inflammation affecting cardiovascular health. Identifying biomarkers of proinflammatory EAT could enhance understanding of impaired microvascular function in women with angina but no obstructive coronary artery disease (ANOCA). Goal(s): This study aims to evaluate EAT fatty acid composition (FAC) and its relationship to myocardial perfusion reserve (MPR) in female ANOCA patients. Approach: Correlations were assessed between MPR and EAT fatty acid fractions quantified using our novel MRI method. Results: Results showed MPR correlates positively with polyunsaturated fatty acids, and negatively with saturated fatty acids, suggesting FAC as a biomarker of proinflammatory EAT. Impact: This study introduces EAT FAC imaging at 1.5T as a potential mechanism of microvascular dysfunction to further investigate in women with ANOCA.
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Echols et al. (2025) studied this question.
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