This analysis demonstrates decreased macromolecular proton fraction and increased magnetic susceptibility in Parkinson's patients, indicating neurodegeneration.
Motivation: Imaging biomarkers are needed to detect neurodegeneration in the prodromal stage and predict disease progression in Parkinson's disease. Goal(s): To assess the utility of macromolecular proton fraction (MPF) mapping and quantitative susceptibility mapping (QSM) of subcortical nuclei for diagnosing Parkinson's disease. Approach: We performed MPF mapping and QSM in patients with Parkinson's disease and healthy controls. Results: In multiple subcortical nuclei, patients with Parkinson's disease showed significantly decreased MPF values and significantly increased magnetic susceptibility values compared with that in healthy controls. Impact: Decreased MPF may reflect neurodegeneration, while increased magnetic susceptibility suggests iron accumulation. Combining MPF and QSM measurements in subcortical nuclei could aid in diagnosing Parkinson's disease.
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Fujiwara et al. (2025) studied this question.
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