A Comprehensive Cortical Analysis for Fetal Growth Restriction using High-resolution MRI

Motivation: Fetal Growth Restriction (FGR) is significant complication that affects approximately 30 million infants annually, with longlasting impacts on brain structure and function. Goal(s): This study aims to advance the understanding of FGR and improve prognosis of affected populations through comprehensive cortical analysis. Approach: We apply super-resolution reconstruction and segmentation algorithms to clinically-acquired fetal brain MR scans, and then reconstruct cortical surfaces and analyze cortical properties across 35 brain regions on 241 fetuses. Results: FGR affects both brain hemispheres equally, with key cortical properties in thickness and sulcal depth. We have developed a regression model to effectively predict FGR using seven key brain regions. Impact: This study analyzes fetal growth restriction (FGR) impacts on cortical development, identifying altered brain regions like the insula, cuneus, and rostral anterior cingulate, affecting sensory integration, cognition, and emotional regulation, and also highlighting areas of both vulnerability and resilience.