LV Late Gadolinium Enhancement for the Primary Prevention of Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy

Motivation: The predictive value of left ventricular late gadolinium enhancement (LV LGE) for arrhythmic events in arrhythmogenic right ventricular cardiomyopathy (ARVC) remains unclear. Goal(s): To explore whether LV LGE serves as an independent predictor of the first episode of sustained ventricular arrhythmia (VA) and enhances the risk stratification of ARVC. Approach: A retrospective analysis of 283 ARVC patients with baseline cardiovascular magnetic resonance (CMR) and no prior sustained VA was conducted, with long-term follow-up. Results: LV LGE extent was independently associated with the first episode of sustained VAs in ARVC and further improve the risk stratification. Impact: Our study demonstrated that LV LGE was independently associated with the first occurrence of sustained VAs in ARVC and could improve risk prediction of the proposed 5-year risk calculator, which might further refine the primary prevention strategies of the disease.