April 4, 2013European Journal of Heart Failure
Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging for the Prediction Of Ventricular Tachyarrhythmic Events: A Meta-Analysis
Why the study?
Does the extent of LV scar on LGE-CMR predict ventricular arrhythmic events in patients with CAD or non-ischaemic cardiomyopathy?
Population
11 studies pooling 1,105 patients with coronary artery disease or non-ischaemic cardiomyopathy and reduced…
Comparison
Late gadolinium enhancement cardiac magnetic… vs Lesser extent or absence of LV scar on LGE-CMR.
Design
Meta-analysis
Follow-up
mean/median 8.5-41 months
Authors
Discussion
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Implication
The extent of late gadolinium enhancement on CMR is strongly associated with ventricular arrhythmias in patients with reduced LVEF, highlighting its potential utility for sudden cardiac death risk stratification.
Structured PICO
Does the extent of LV scar on LGE-CMR predict ventricular arrhythmic events in patients with CAD or non-ischaemic cardiomyopathy?
P
Population
11 studies pooling 1,105 patients with coronary artery disease (CAD) or non-ischaemic cardiomyopathy and reduced LVEF.
I
Intervention
Late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR) assessing the extent of left ventricular (LV) scar.
C
Comparator
Lesser extent or absence of LV scar on LGE-CMR.
O
Outcome
Ventricular arrhythmic events (composite of sudden cardiac death, resuscitated cardiac arrest, occurrence of ventricular arrhythmias, or appropriate implantable cardioverter defibrillator [ICD] therapy).composite
The extent of late gadolinium enhancement on CMR is strongly associated with ventricular arrhythmias in patients with reduced LVEF, highlighting its potential utility for sudden cardiac death risk stratification.
Limitations
- Small sample sizes of individual included studies
- Uncertainties regarding clinical application persist
Cite This Study
Scott et al. (2013) studied this question.