April 15, 2011Circulation Arrhythmia and ElectrophysiologyOpen Access

The Extent of Left Ventricular Scar Quantified by Late Gadolinium Enhancement MRI Is Associated With Spontaneous Ventricular Arrhythmias in Patients With Coronary Artery Disease and Implantable Cardioverter-Defibrillators

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Why the study?

Is the extent of left ventricular scar quantified by LGE-CMR associated with appropriate ICD therapy in patients with coronary artery disease?

Population

64 patients with coronary artery disease and implantable cardioverter-defibrillators who underwent LGE-CMR…

Design

Cohort

Follow-up

19±10 months

Authors

PSPaul A. ScottKing's College London JMJohn M. MorganUniversity Hospital Southampton NHS Foundation Trust NCNicola CarrollUniversity of Leeds

Discussion

Member takes

Implication

May support LGE-CMR scar assessment for ICD risk stratification in CAD; leaves open prospective validation before practice change.

Structured PICO

Is the extent of left ventricular scar quantified by LGE-CMR associated with appropriate ICD therapy in patients with coronary artery disease?

Population

64 patients with coronary artery disease and implantable cardioverter-defibrillators (ICDs) who underwent LGE-CMR before ICD implantation, mean age 66±11 years, 51 male.

Intervention

Extent and distribution of left ventricular scar quantified using late gadolinium enhancement cardiac MRI (LGE-CMR), including percent scar, scar surface area, and number of transmural left ventricular scar segments.

Outcome

Appropriate ICD therapyhard clinical

The extent of myocardial scar quantified by LGE-CMR is significantly associated with spontaneous ventricular arrhythmias and appropriate ICD therapy in patients with coronary artery disease.

Limitations

Pilot study (small sample size)
Retrospective design
Single-center

Cite This Study

Scott et al. (2011) studied this question.

synapsesocial.com/papers/6a8388aa0bb779da6111ac57 https://doi.org/10.1161/circep.110.959544

Topics

Ventricular arrhythmias Cardiac device therapy Coronary artery disease

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The Extent of Left Ventricular Scar Quantified by Late Gadolinium Enhancement MRI Is Associated With Spontaneous Ventricular Arrhythmias in Patients With Coronary Artery Disease and Implantable Cardioverter-Defibrillators

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

The Extent of Left Ventricular Scar Quantified by Late Gadolinium Enhancement MRI Is Associated With Spontaneous Ventricular Arrhythmias in Patients With Coronary Artery Disease and Implantable Cardioverter-Defibrillators

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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