Key result
Total myocardial scar mass (HR 1.02) and border zone mass (HR 1.04) independently predicted appropriate ICD therapy in patients with ischemic cardiomyopathy.
Why the study?
ICD therapy has deleterious effects that antiarrhythmic drugs or catheter ablation can reduce, but it is largely unknown which patients might benefit, prompting evaluation of whether myocardial scar characterization improves risk stratification for ventricular arrhythmias.
Does LGE-CMR-based myocardial scar characterization predict appropriate ICD therapy in patients with ischemic cardiomyopathy?
Population
82 patients with ischemic cardiomyopathy who received an ICD
Comparison
Myocardial scar characterization via LGE-CMR vs ECG QRS complex data
Design
Retrospective study
Follow-up
Median 3.98 years
Authors
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Scar characterization may aid VA risk stratification in ischemic cardiomyopathy ICD patients; leaves open whether it should guide therapy selection.
Observational (n=82)
No
Does LGE-CMR-based myocardial scar characterization predict appropriate ICD therapy in patients with ischemic cardiomyopathy?
Hazard Ratio: 1.02 (95% CI 1–1.04)
p-value: p=0.014
LGE-CMR-based quantification of total scar and border zone mass, but not ECG characteristics, independently predicts the occurrence of ventricular arrhythmias requiring appropriate ICD therapy in patients with ischemic cardiomyopathy.
Noordman et al. (2021) conducted an observational in Ischemic cardiomyopathy (n=82). Total myocardial scar mass was evaluated on Appropriate ICD therapy (HR 1.02, 95% CI 1.00-1.04, p=0.014). Total myocardial scar mass (HR 1.02) and border zone mass (HR 1.04) independently predicted appropriate ICD therapy in patients with ischemic cardiomyopathy.
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