Key result
The presence of late gadolinium enhancement on cardiac MRI was associated with a 4-fold increased risk of major ventricular arrhythmic events (OR 3.99) in nonischemic dilated cardiomyopathy.
Why the study?
Risk stratification based mainly on left ventricular ejection fraction impairment has limited performance in NIDCM, prompting evaluation of the prognostic value of LGE on long-term arrhythmic and mortality outcomes.
Does the presence of LGE on CMR predict adverse long-term arrhythmic and mortality outcomes in patients with nonischemic dilated cardiomyopathy?
Population
15,217 patients with NIDCM across 60 studies
Comparison
Presence of LGE vs absence of LGE on CMR
Design
Systematic review and random-effects meta-analysis
Follow-up
3-year median
Authors
Loading...
LGE on CMR may refine ICD risk stratification in NIDCM; extends observational evidence but leaves practice change open pending RCTs.
Meta-Analysis (n=15,217)
Does the presence of LGE on CMR predict adverse long-term arrhythmic and mortality outcomes in patients with nonischemic dilated cardiomyopathy?
Odds Ratio: 3.99 (95% CI 3.08–5.16)
The presence of LGE on CMR is a strong predictor of adverse long-term outcomes in patients with NIDCM, suggesting its utility in risk stratification for primary prophylactic ICD placement.
Theerasuwipakorn et al. (2023) conducted a meta-analysis in Nonischemic dilated cardiomyopathy (n=15,217). Presence of late gadolinium enhancement (LGE) on cardiac MRI vs. Absence of LGE was evaluated on Major ventricular arrhythmic events (OR 3.99, 95% CI 3.08, 5.16). The presence of late gadolinium enhancement on cardiac MRI was associated with a 4-fold increased risk of major ventricular arrhythmic events (OR 3.99) in nonischemic dilated cardiomyopathy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: