Two-Dimensional T1-T2 Encoded Pulse Sequence Development at 0.064T

Motivation: Advancing the capabilities to characterize tissue microstructure on ultra-low field (ULF) MRI scanners enables large-scale longitudinal studies of brain developmental trajectories in normal and diseased pediatric populations. Goal(s): To develop and vet new multi-dimensional MRI (mdMRI) sequences and processing pipelines for use in following brain developmental trajectories in pediatric subjects, which has never been demonstrated previously on ultralow-field MRI scanners. Approach: We design, implement, and vet mdMRI pulse sequences on an ULF MRI scanner using quantitative diffusometry and relaxometry MRI phantoms. Results: Good progress has been made migrating multi-dimensional MRI methods developed for high-field to ULF MRI scanners, which poses many challenges. Impact: Little is known about healthy brain development of children in LMICs, where there is limited access to radiology. This project intends to improve our understanding of determinants of brain health and help democratize access to radiological resources worldwide.