Cross-sectional analysis shows early neurochemical development in infants, suggesting significant implications for understanding neurodevelopment.
Motivation: Neurometabolite concentration changes in the first few months after birth have not been studied in a large cohort. Goal(s): To assess early neurochemical development in a large cohort of 0-8 month-old infants by analyzing all available data in the first MRS data release of the HEALthy Brain and Child Development study ("HBCD"). Approach: Linear combination modeling will quantify 14 neurometabolites in this cross-sectional population. Statistical analyses will test for significant relationships between metabolite levels, birth-age and gestational age. Impact: Identifying changes in neurochemical levels in the first few months after birth in a large cohort for the first time will help deepen our understanding of the various roles these chemicals play in neurodevelopment.
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Murali‐Manohar et al. (2025) studied this question.
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