Dynamic network dysfunction in children with idiopathic generalized epilepsy correlated with cognitive impairment and gene expression

Motivation: Idiopathic generalized epilepsy (IGE) is a network disease and also a highly heritable disorder, genetic variations and recurrent seizures may result in network reconfiguration and cognitive impairments. Goal(s): We aimed to explore the dynamic changes in functional network in IGE children and the relationship with cognitive impairment and gene expression profiles. Approach: We use the resting-state functional MRI data to constructed time-varying multi-layer network,the dynamic network remodeling in IGE was correlated with Allen Human Brain Atlas to identify relative gene sets. Results: We reported disrupted dynamic functional connectivity in children with IGE and its correlation with cognitive function and gene expression. Impact: These findings reveals the complex relationship between the dynamic changes of macroscopic modules and genetic pathological mechanisms in IGE patients and improves our comprehension the neurobiological mechanisms that underlie cognitive function.