Optimizing of Flourine-19 at 7T MRI in large animal model after Acute Myocardial infarction.

Motivation: Fluorine MRI has been used to track the fate of immune cells , as well as raised widespread interest in the clinical setting. However, 19F MRI signal at ultra-high-field (UHF) has poor detection sensitivity compared to other imaging modalities. Goal(s): Nevertheless, its exact contribution to this process has not yet been investigated at 7T MRI with a large animal model. Approach: To address this, we investigated 19F MRI on Phantoms and in a large animal model of AMI at UHF MRI. Results: Our results suggest a TruFISP sequence and its rapid acquisition time as beneficial for 19F MRI signal detection in the targeted regions. Impact: The present work represents an MRI approach to test time and intensity of 19F signal i (ex vivo & in vivo) in large animal after AMI.