Longitudinal study reveals association between reduced cerebral blood flow and cognitive functions in elderly, suggesting new biomarker potential.
Motivation: Developing and validating an imaging biomarker at an individual level could help improve precision medicine for clinical diagnosis and treatment of neurodegenerative diseases. Cerebral blood flow (CBF) has been revealed as an important biomarker for Alzheimer's disease (AD). However, the temporal correlation between CBF and cognitive function is rarely reported at an individual level. Goal(s): To investigate the relationship of longitudinal CBF changes with corresponding temporal changes in cognitive functions. Approach: Generalized estimating equations (GEE) was used for the repeated measure correlation between region-specific CBF and cognitive functions. Results: A faster longitudinal CBF reduction is strongly associated with worsened temporal cognitive functions. Impact: This study fills the gap of research in the association between longitudinal changes of CBF and cognitive functions at an individual level.
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Zhao et al. (2025) studied this question.
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