Key result
Reduced cerebral blood flow on SPECT links to worse cognitive function in Alzheimer's disease.
Why the study?
An observer-independent semiquantitative analysis method for brain SPECT imaging in Alzheimer's disease patients was evaluated to assess cortical perfusion abnormalities.
Does observer-independent semiquantitative analysis of SPECT data correlate with cognitive functioning in patients with Alzheimer's disease?
Population
45 patients with clinical diagnosis of Alzheimer's disease and 10 cognitively intact controls of comparable age
Comparison
Alzheimer's disease patients vs cognitively intact controls
Design
Cross-sectional study using 99mTc-ethylcysteine dimer SPECT with three-dimensional stereotactic surface projection
Authors
Loading...
Observer-independent SPECT analysis may aid objective AD perfusion assessment; leaves open routine adoption without prospective validation.
Cross-Sectional (n=55)
Does observer-independent semiquantitative analysis of SPECT data correlate with cognitive functioning in patients with Alzheimer's disease?
Observer-independent analysis of SPECT data provides a valid assessment of cortical perfusion abnormalities that correlates with cognitive impairment in Alzheimer's disease.
Hirsch et al. (1997) conducted a cross-sectional in Alzheimer's disease (n=55). 99mTc-ethylcysteine dimer SPECT with observer-independent semiquantitative analysis vs. Cognitively intact controls was evaluated on Association between global relative decrease of cerebral blood flow and overall level of cognitive functioning. Observer-independent semiquantitative analysis of 99mTc-ECD SPECT revealed a significant inverse association between cerebral blood flow reduction and cognitive functioning in Alzheimer's disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: