Cohort study demonstrates a significant link between choroid plexus volume and lobar cerebral microbleeds, suggesting cerebrospinal fluid clearance impairment.
Motivation: Lobar cerebral microbleeds (CMBs) are linked to cerebral amyloid angiopathy (CAA). Evidence indicates impaired cerebrospinal fluid (CSF) clearance in CAA, but large-scale studies on CMBs and CSF clearance parameters are lacking. Goal(s): To investigate if lobar CMBs are associated with MRI markers of impaired CSF clearance, specifically increased choroid plexus volume (CPV), enlarged perivascular spaces (EPVS), and increased lateral ventricle volume (LVV). Approach: This cross-sectional study included 2,082 elderly participants. MRI data, including CPV, EPVS, and LVV, were analyzed Results: Lobar CMBs correlated with CPV, suggesting CSF clearance impairment, while deep CMBs showed no association. Impact: This study found a significant association between lobar CMBs and CPV in a large elderly population, including healthy individuals and those with mild cognitive impairment (MCI), suggesting the potential clinical relevance of lobar CMBs in MCI and asymptomatic groups.
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Saito et al. (2025) studied this question.
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