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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Identifying Brain Degeneration Patterns in Early-Stage Parkinson's Disease: A Multimodal MRI Study

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Authors

ZZZiyu ZhuNaval Medical Research CommandJWJiaqi WenGuangxi Maternal and Child Health HospitalQZQianshi ZhengWomen's Hospital, School of Medicine, Zhejiang University

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Implication

This multimodal MRI study identifies brain degeneration subtypes in early-stage Parkinson's disease, suggesting clinical relevance.

Key Points

  • A subtype with malignant brain degeneration was identified, showing pronounced clinical symptoms at baseline.
  • Another subtype exhibited initial neuroadaptive changes with mild symptoms at baseline but accelerated progression during follow-up.
  • Multimodal MRI was used to assess cortical morphology, white matter microstructure, and subcortical iron metabolism.
  • The classification strategy offered new insights into early neurodegenerative heterogeneities in Parkinson's disease patients.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68d45b1b31b076d99fa5d3e2https://doi.org/10.58530/2025/4536
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1GR.3 Distinct longitudinal brain atrophy trajectories in parkinson’s disease clinical subtypes: insight towards precision medicine2024
  2. 2Multimodal magnetic resonance imaging-based clustering identifies two imaging-defined brain phenotypes in De novo Parkinson's disease2026
  3. 3Distinct Longitudinal Clinical-Neuroanatomical Trajectories in Parkinson’s Disease Clinical Subtypes: Insight Towards Precision Medicine2024 · 3 citations
  4. 4Data-Driven MRI-Based Subtyping of Parkinson's Disease Reveals Cortex-First and Deep Grey-First Progression Patterns2025 · 1 citations
  5. 5Data Driven Subtyping Reveals Two Distinctive Patterns of Deep Gray Matter atrophy and Dopamine Availability in early Parkinson’s Disease2025 · 1 citations