Analysis reveals higher plasma neurofilament light correlates with less brain tissue and increased white matter hyperintensities in older adults, indicating broader implications for brain health.
Motivation: The relation of plasma neurofilament light (NfL), a marker of neuronal damage, with brain characteristics is not well understood. Goal(s): Investigation the relation of NfL with brain morphometry and white matter hyperintensity (WMH) volume in non-demented older adults. Approach: We analyzed NfL, brain morphometry, and WMH volume in 202 community-based older adults. Results: Higher NfL levels were linked to less brain tissue, larger ventricles and higher WMH volume, suggesting NfL's sensitivity to both neurodegenerative and vascular changes. Impact: This study positions NfL as a non-specific marker of age-related brain pathology, supporting its use for broader assessment of brain health in clinical settings.
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Saifullah et al. (2025) studied this question.
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