MRI-Based Quantification of CSF Flow as a Diagnostic and Prognostic Marker in Idiopathic Intracranial Hypertension: a North-African Study

Motivation: The pathophysiology of idiopathic intracranial hypertension (IIH) remains unclear, though restricted CSF outflow and increased pressure are central factors. Goal(s): To assess MRI-based CSF flow quantification as a diagnostic tool and predictor of clinical outcomes in IIH, focusing on metrics associated with intracranial pressure (ICP) and optic nerve pathology. Approach: Flow-sensitive MRI sequences measured CSF flow parameters in IIH patients and controls, including peak systolic velocity and mean flow rate in key brain regions. CSF abnormalities were analyzed alongside ICP, optic disc edema, and visual outcomes. Results: IIH patients showed significantly lower CSF velocity and volume, correlating with increased ICP and optic pathology. Impact: Quantitative MRI of CSF flow offers a non-invasive diagnostic tool that correlates closely with IIH markers and optic pathology. This technique holds promise for identifying high-risk patients, guiding early intervention, and potentially monitoring treatment efficacy in IIH management.