Plasma proteomics to profile neurobiological mechanisms of chronic pain

Motivation: Although increasing diverse sets of biological mechanisms related to chronic pain, there is a limited understanding of neurobiological mechanisms relevant to chronic pain and its prognosis. Goal(s): This study delineates both common and site-specific proteins linked to various chronic pain conditions, elucidating their implications across molecular pathways, health status, and diseases. Approach: This study used phenome-wide association, pathway enrichment and tissue expression, Mendelian randomization, and LightGBM model. Results: This study delineates proteins associated with various chronic pain conditions, elucidating their implications across biological pathways and health status. Furthermore, we identified proteins that were capable of predicting the occurrence and spreading of chronic pain. Impact: This study delineates proteins associated with various chronic pain conditions, elucidating their implications across neurobiological pathways. Furthermore, we identified proteins that were capable of predicting the occurrence and spreading of chronic pain. These findings benefit both research and clinical practice.