What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Brain perfusion and permeability change in Alzheimer's Disease patients.

Key Points

Higher blood brain barrier permeability in Alzheimer's Disease compared to healthy controls highlights neurovascular changes that may influence cognitive decline.
Positive correlation observed between cognitive assessment scores and cerebral blood flow indicates hypoperfusion aligns with cognitive impairment in Alzheimer's patients.
MRI methods effectively capture changes in brain perfusion and permeability across different stages of Alzheimer's Disease and mild cognitive impairment.
Results suggest that disruptions in blood brain barrier and reduced cerebral blood flow may play pivotal roles in Alzheimer's Disease progression.

Abstract

Motivation: Investigation of neurovascular pathophysiologic change in Alzheimer's Disease (AD) Goal(s): Investigation of cerebral perfusion and permeability changes in AD versus mild cognitive impaired (NCI) and healthy control (HC) groups. Approach: Cerebral blood flow (CBF) and blood brain barrier (BBB) permeability were acquired using arterial spin labeling and dynamic contrast enhanced MR imaging in AD dementia (n=7), MCI (n=20) and HC (n=19). Results: We find that higher permeability in subcortical gray matter (GM) and GM lobes in AD than in HC. We observe that cognitive assessment score is positively correlated to CBF in GM, indicating that hypoperfusion in GM parallels cognitive decline. Impact: Cognitive impairment could be linked to neurovascular BBB disruption and CBF reduction.BBB and CBF changes can be distinctly captured by MRI methods in both MCI and dementia stages of AD. The degree of these changes relates to stage of AD.

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