Answers are grounded in this paper and cite their sources.
In vivo MRI and ex vivo immunofluorescence reveal brain changes due to obesity, suggesting celastrol reverses neuroinflammation.
Motivation: Obesity is a prevalent pathology that has a negative impact on human health. The cerebral changes that underly its development and treatment are under current investigation, and could be key in determining the fate of this disease. Goal(s): To reveal the mouse brain changes underlying obesity development and treatment. Approach: In vivo MRI and ex vivo immunofluorescence of the brain of obese or lean animals, before and after treatment with celastrol, a pre-clinical compound that induces body weight loss. Results: In vivo diffusion tensor parameters and ex vivo markers of microglisis and astrocytosis consistent with obesity-induced neuroinflammation that are reversed with celastrol. Impact: The standardization of MRI techniques that could reveal the brain changes underlying obesity development and treatment could boost the development of improved anti-obesity drugs and the understanding of its action mechanisms.
No takes yet. Share an insight, caveat, or question.
Ferreiro et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: