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September 17, 2025JAMA Network OpenOpen Access

PREVENT and PCE Models for Estimating ASCVD Risk Stratified by Statin Exposure

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Authors

MLMing‐Sum LeeJOJames OnwuzurikeYWYi‐Lin Wu

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Overview

Retrospective cohort analysis shows PREVENT underestimates ASCVD risk in non-statin users, suggesting PCE may be more accurate.

Key Points

  • The PCE model more accurately reflected observed ASCVD risk in patients not exposed to statins, compared to PREVENT.
  • Among 193,885 adults, the C statistic was 0.725 for PCE and 0.723 for PREVENT in estimating ASCVD risk.
  • The observed ASCVD risk was lower than estimated by PCE in the overall population, indicating discrepancies in model performance.
  • PREVENT underestimated risk in non-statin users while PCE provided closer approximations to actual observed risks.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68d45b2931b076d99fa5da0dhttps://doi.org/10.1001/jamanetworkopen.2025.32164
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