March 1, 2025International Journal of Clinical and Translational MedicineOpen Access
The Role of Risk Equations in Primary Prevention of Atherosclerotic Cardiovascular Disease
Why the study?
Following the release of the PREVENT risk equations, an overview was needed on cardiovascular risk assessment in primary prevention and the performance of PREVENT compared to the pooled cohort equations.
Do the PREVENT risk equations provide superior cardiovascular risk assessment compared to the pooled cohort equations in primary prevention?
Comparison
PREVENT risk equations vs pooled cohort equations (PCE)
Design
Review
Authors
Discussion
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Member takes
Implication
May support PREVENT adoption in primary prevention; leaves open prospective validation before practice change.
Structured PICO
Do the PREVENT risk equations provide superior cardiovascular risk assessment compared to the pooled cohort equations in primary prevention?
P
Population
Individuals in primary prevention (aged 30-79 years for PREVENT, 40-75 years for PCE) without a history of ASCVD
I
Intervention
PREVENT risk equations
C
Comparator
Pooled cohort equations (PCE)
O
Outcome
Performance of risk assessment (calibration and discrimination) for 10- and 30-year ASCVD, CVD, and HF risk
The PREVENT risk equations provide superior calibration and discrimination compared to the pooled cohort equations for ASCVD risk assessment in primary prevention.
Limitations
- Additional research is essential to define clinical thresholds
- Need to evaluate potential in directing the use of emerging preventive therapies
Cite This Study
Rikhi et al. (2025) studied this question.