Experimental analysis shows that andrographolide induces ferroptosis in liver cancer cells, suppressing the AKT-mTOR pathway and GPX4 protein.
Andrographolide is a potential drug to alleviate liver cancer by inducing ferroptosis in the cancer cells. In this article, a series of experiments would be conducted to test whether it has positive results on cancer killing. In addition, we would find out the mechanism between Andrographolide and ferroptosis. Furthermore, methods would also be used to identify the target site of Andrographolide inside the human body. Those possible outcomes in this article could help to a creative understanding of how Andrographolide inhibits hepatoma.
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J. Zhang (2025) studied this question.
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