Is it possible that combined alpha-tocopherol and CoQ10 can combat testicular injury induced by arsenic

Arsenic emerges as a significant public health issue. Therefore, it makes sense to identify appropriate compounds to alleviate arsenic toxicity. Alpha-tocopherol and Coenzyme Q10 were tested for their ability to avert arsenic effects. 30 mice were recruited and divided into 5 groups, each consisting of six animals. The mice in these 5 groups were exposed to drinking water (136 parts per million of arsenic). The whole duration was 30 days. The control group received only free distilled water. The arsenic (As) group was treated with water containing arsenic. (As+α-tocopherol) group received arsenic and alpha-tocopherol (50 mg/kg bw). The As+CoQ10 group was treated with arsenic and CoQ10 (10 mg/kg b.wt.), while the As+α-tocopherol+CoQ10 group was treated with arsenic and a combination of both. According to biochemical data, the group exposed to arsenic had significantly lower levels of reduced glutathione, total thiol, and superoxide dismutase than the control group, while its level of lipid peroxidation was higher. Antioxidant treatment mitigated these changes. Alpha-tocopherol, CoQ10, and a combination of these substances reduce the changes caused by arsenic, which causes DNA damage in blood cells by exhibiting a significantly lower head DNA percentage and a higher tail DNA percentage, tail length, and tail moment. In conclusion, Alpha-tocopherol and CoQ10 together is more effective than using these antioxidants separately against arsenic.